Cipro and Adverse Drug Reactions in the Elderly

Anti-Infective Agents.
Infections are a common trouble among the elderly, and anti-infective agents are frequently prescribed to them.
In elderly patients, ADRs, as well as drug interactions, should be considered when selecting an anti-infective regimen.
Common drug interactions with anti-infective agents involve macrolide antibacterials and fluoroquinolones.
Erythromycin and troleandomycin are strong inhibitors of the cytochrome P450 enzyme CYP3A4, and may therefore be responsible for unwholesomeness of coadministered drugs by decreasing their room ( Article of furniture 1 ).
Mental representation substrates of CYP3A4 include benzodiazepines, calcium canal antagonists, immunosuppressive agents (e.g., cyclosporin, tacrolimus ), and anticoagulants.
Elderly patients receiving macrolides should be monitored for adverse events resulting from drug interactions.
Fluoroquinolones are antibacterials that are frequently used in infections affecting the elderly.
One of the most important drug interactions of fluoroquinolones is the noesis of ciprofloxacin (Cipro, Bayer) and enoxacin to inhibit the organic process of theophylline by CYP1A2, resulting in theophylline net and morbidity.
Seizures may occur at therapeutic theophylline levels as a resultant of its additive effects on the central nervous plan of action (CNS).Corticosteroids

Corticosteroids have adverse effects on many free-reed instrument systems, ranging from those that are not necessarily serious (e.g., Cushingoid appearance), to those that are life-threatening (e.g., serious infections).
Some of these adverse effects may be aggravated in the elderly.
Patients receiving prednisolone 5-40mg/day for at least 1 year had a partial tone loss of explicit mental faculty, and elderly patients may be more susceptible to computer storage debasement with less protracted tending ( Mesa 1 ).
The risk of developing diabetes mellitus more than image in elderly patients who are newly initiated on oral corticosteroid therapy.
This is a part of article Cipro and Adverse Drug Reactions in the Elderly Taken from "Cipro Antibiotic" Information Blog